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Approved Antineoplastic Agents Reference Data

The Biological Testing Branch conducted a literature search in August 2008 to determine the number of references that existed for mouse xenografts associated with these agents. The search was conducted using the SciFinder® 2007 database search tool with the following criteria selected: [1] includes journals, reviews, conferences, and clinical trials; [2] excludes patents; [3] the keywords were compound name, xenograft, mouse; and [4] includes word combinations that were present and/or all concepts to be found in cited references.

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AGENT YEAR INTRODUCED # OF REFERENCES YIELDED
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PPI-2458 [abarelix, plenaxis] PPI-2458 [abarelix, plenaxis] 2004 1
aclarubicin aclarubicin 1981 4
actinomycin D actinomycin D 1964 10
aldesleukin aldesleukin 1992 1
alemtuzumab alemtuzumab 2001 1
alitretinoin alitretinoin 1999 10
aminoglutethimide aminoglutethimide 1981 5
amrubicin HCl amrubicin HCl 2002 5
amsacrine amsacrine 1987 21
anastrozole anastrozole 1995 2
angiotensin II angiotensin II 1994 8
arglabin   1999 0
arsenic trioxide arsenic trioxide 2000 12
asparaginase asparaginase 1969 6
azacytidine azacytidine Pre-1977 2
bcg live   1990 0
CKD-602 [belotecan hydrocholoride] CKD-602 [belotecan hydrocholoride] 2004 2
bevacizumab bevacizumab 2004 15
bexarotene bexarotene 2000 11
bicalutamide bicalutamide 1995 3
bisantrene hydrochloride bisantrene hydrochloride 1990 1
bleomycin bleomycin 1966 26
bortezomib bortezomib 2003 14
busulfan busulfan 1954 7
calusterone [dimethyltestosterone]   1973 0
camostat mesylate camostat mesylate 1985 1
capecitabine capecitabine 1998 20
carboplatin carboplatin 1986 40
carmofur carmofur 1981 11
carmustine [BCNU] carmustine [BCNU] 1977 48
carzinophilin [carzinophyllin]   1954 0
celmoleukin [tucotuzumab, EMD273066]   1992 0
cetuximab cetuximab 2003 27
chlorambucil chlorambucil 1956 2
TACE [chlortrianisene, trioxifene, LY133314] TACE [chlortrianisene, trioxifene, LY133314] Pre-1981 1
chromomycin A3 chromomycin A3 1961 4
cis-diamminedichloroplatinum cis-diamminedichloroplatinum 1979 116
cladribine cladribine 1993 4
clofarabine clofarabine 2005 2
cyclophosphamide cyclophosphamide 1957 101
cytarabine ocfosfate cytarabine ocfosfate 1993 1
cytosine arabinoside cytosine arabinoside 1969 16
DTIC [dacarbazine] DTIC [dacarbazine] 1975 11
dasatinib dasatinib 2006 3
daunomycin daunomycin 1967 7
decitabine decitabine 2006 12
ONTAK [denileukin diftitox, DAB389 IL-2] ONTAK [denileukin diftitox, DAB389 IL-2] 1999 1
dexamethasone dexamethasone 1958 15
diethylstilbestrol diethylstilbestrol Pre-1970 15
docetaxel docetaxel 1995 68
doxifluridine doxifluridine 1987 54
doxorubicin doxorubicin 1966 180
dromostanolone [masteron]   1961 0
elliptinium acetate elliptinium acetate 1983 1
enocitabine enocitabine 1983 1
epirubicin HCL >epirubicin HCL 1984 6
erlotinib hydrochloride erlotinib hydrochloride 2004 14
estramustine estramustine 1980 4
ethinyl estradiol [estradiol] ethinyl estradiol [estradiol] Pre-1970 2 [56]
etoposide etoposide 1980 42
exemestane exemestane 1999 5
fadrozole HCL fadrozole HCL 1995 1
floxuridine floxuridine 1971 66
fludarabine phosphate fludarabine phosphate 1991 18
fluorouracil fluorouracil 1962 162
fluoxymesterone [halotestin]   Pre-1970 0
flutamide flutamide 1983 18
formestane formestane 1993 6
fosfestrol   Pre-1977 0
fotemustine fotemustine 1989 6
ftorafur ftorafur 1972 92
fulvestrant fulvestrant 2002 6
gefitinib gefitinib 2002 37
gemcitabine HCL gemcitabine HCL 1995 77
gemtuzumab ozogamicin gemtuzumab ozogamicin 2000 2
goserelin acetate goserelin acetate 1987 1
H-101 [gendicine]   2005 0
heptaplatin heptaplatin 1999 1
hexamethylmelamine hexamethylmelamine 1979 6
hexyl [5] aminolevulinate hexyl [5] aminolevulinate 2004 4
histrelin [vantas, supprelin LA]   2004 0
hydroxyprogesterone hydroxyprogesterone Pre-1970 3
hydroxyurea hydroxyurea 1968 21
idarubicin hydrochloride idarubicin hydrochloride 1990 1
ifosfamide ifosfamide 1976 15
imatinib imatinib 2001 16
interferon alpha-2a interferon alpha-2a 1986 7
interferon alpha-2b interferon alpha-2b 1986 4
interferon gamma-1a interferon gamma-1a 1992 1
interleukin-2 interleukin-2 1989 50
irinotecan irinotecan 1994 45
lenalidomide lenalidomide 2005 6
letrozole letrozole 1996 4
leucovorin leucovorin 1950 9
leuprolide leuprolide 1984 2
levamisole levamisole Pre-1981 2
lobaplatin lobaplatin 1998 1
lomustine [CCNU] lomustine [CCNU] 1976 3 [5]
lonidamine lonidamine 1987 1
nordihydroguaiaretic acid [NDGA, masoprocol, actinex] nordihydroguaiaretic acid [NDGA, masoprocol, actinex] 1992 14
nitrogen mustard [mechlorethanamine] nitrogen mustard [mechlorethanamine] 1958 46
medroxyprogesterone medroxyprogesterone 1958 20
megesterol acetate megesterol acetate 1971 1
melanoma theraccine [melacine]   2001 0
melphalan melphalan 1961 38
mercaptopurine mercaptopurine 1953 8
methotrexate methotrexate 1954 45
methylprednisolone methylprednisolone 1955 10
methyltestosterone   1974 0
miltefosine miltefosine 1993 2
mithramycin mithramycin 1961 7
mitobronitol   1979 0
mitomycin C mitomycin C 1956 81
mitotane mitotane 1970 1
mitoxantrone mitoxantrone 1984 8
mobenakin   1999 0
nadrolone phenylpropionate [durabol]   1959 0
nafoxidine nafoxidine Pre-1977 1
nedaplatin nedaplatin 1995 17
nelarabine [arranon]   2005 0
neocarzinostatin neocarzinostatin 1976 6
nilutamide   1987 0
nimustine nimustine Pre-1981 3
norethindrone norethindrone Pre-1977 1
oxaliplatin oxaliplatin 1996 16
paclitaxel paclitaxel 1993 162
paclitaxel nanoparticles paclitaxel nanoparticles 2005 2
pamidronate pamidronate 1987 4
pegaspargase   1994 0
pemetrexed pemetrexed 2004 2
pentostatin [deoxycoformycin, nipent]   1992 0
peplomycin peplomycin 1981 16
pipobroman [vercyte, NSC 25154]   1966 0
pirarubicin pirarubicin 1988 15
porfimer sodium porfimer sodium 1993 7
prednisolone prednisolone Pre-1977 2
prednisone prednisone Pre-1970 12
procarbazine procarbazine 1969 6
raltitrexed raltitrexed 1996 14
ranimustine ranimustine 1987 1
razoxane razoxane Pre-1977 6
rituximab rituximab 1997 19
sarkomycin   1954 0
semustine semustine Pre-1977 27
sobuzoxane sobuzoxane 1994 3
solamargine [coramsine]   1987 0
sorafenib sorafenib 2005 5
streptozocin streptozocin Pre-1977 3
sunitinib sunitinib 2006 4
tamibarotene tamibarotene 2005 1
tamoxifen tamoxifen 1973 64
Tumor necrosis factor alpha/a [tasonermin, beromun] Tumor necrosis factor alpha/a [tasonermin, beromun] 1999 10
teceleukin [human IL-2 immunace]   1992 0
temozolomide temozolomide 1999 30
teniposide teniposide 1967 2
testolactone [teslac, fludestrin]   1969 0
testosterone testosterone Pre-1970 24
thioguanine thioguanine 1966 8
thiotepa thiotepa 1959 4
topotecan topotecan 1996 46
toremifene toremifene 1989 1
tositumomab tositumomab 2003 3
trastuzumab trastuzumab 1998 36
triamcinolone triamcinolone 1958 5
triethylenemelamine [TEM]   Pre-1981 0
triptorelin triptorelin 1986 4
uracil mustard [uramustine]   1966 0
valrubicin valrubicin 1999 4
vapreotide vapreotide 2003 20
vinblastine vinblastine 1965 30
vincristine vincristine 1963 49
vindesine vindesine 1979 14
vinorelbine vinorelbine 1989 17
zinostatin stimalamer [YM881, SMANCS]   1994 0
zoledronic acid zoledronic acid 2000 19

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