GI50 Mean Graph for Compound S664704

Results from the National Cancer Institute Human Tumor Cell Line Screen

These results provided by the Developmental Therapeutics Program, DCTD, NCI

Highest concentration tested is 1.0E-04 M; Average GI50 over all cell lines is 4.2E-05 M

Panel Cell Line log(GI50) | Least Sensitive Most Sensitive |
Leukemia CCRF-CEM -5.3
Leukemia HL-60(TB) -5.3
Leukemia K-562 -4.3

Leukemia MOLT-4 -4.9
Leukemia RPMI-8226 -4.7
Leukemia SR -5.4
Non-Small Cell Lung A549/ATCC -4.0

Non-Small Cell Lung EKVX -4.0

Non-Small Cell Lung HOP-62 -4.2

Non-Small Cell Lung HOP-92 -4.0

Non-Small Cell Lung NCI-H226 -4.0

Non-Small Cell Lung NCI-H23 -4.0

Non-Small Cell Lung NCI-H322M -4.0

Non-Small Cell Lung NCI-H460 -4.0

Non-Small Cell Lung NCI-H522 -4.0

Colon COLO 205 -4.0

Colon HCC-2998 -4.0

Colon HCT-116 -5.7
Colon HCT-15 -5.4
Colon HT29 -5.3
Colon KM12 -5.6
Central Nervous System SF-268 -4.1

Central Nervous System SF-295 -4.0

Central Nervous System SF-539 -5.6
Central Nervous System SNB-19 -4.1

Central Nervous System SNB-75 -4.3

Central Nervous System U251 -4.3

Melanoma LOX IMVI -5.3
Melanoma MALME-3M -4.0

Melanoma M14 -4.0

Melanoma SK-MEL-2 -4.0

Melanoma SK-MEL-28 -4.2

Melanoma SK-MEL-5 -4.5
Melanoma UACC-257 -4.0

Melanoma UACC-62 -4.0

Ovarian IGROV1 -5.0
Ovarian OVCAR-3 -5.4
Ovarian OVCAR-4 -4.0

Ovarian OVCAR-5 -4.0

Ovarian OVCAR-8 -4.0

Ovarian SK-OV-3 -4.0

Renal 786-0 -4.3

Renal A498 -4.0

Renal ACHN -4.0

Renal CAKI-1 -5.0
Renal RXF 393 -5.3
Renal SN12C -4.0

Renal TK-10 -4.0

Renal UO-31 -4.0

Prostate PC-3 -4.0

Prostate DU-145 -4.0

Breast NCI/ADR-RES -4.0

Breast MDA-MB-231/ATCC -4.0

Breast HS 578T -4.0

Breast MDA-MB-435 -4.0

Breast MDA-N -4.0

Breast T-47D -4.0