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Open Repository Program

This program was established in 1992 to enable the extramural community to investigate NPR materials, which have not met the current requirements of the NCI screens, as potential sources of agents for the treatment of all human diseases. As of February, 1999, the program was expanded to include all human diseases. As of February, 1999, there were over 100,000 extracts in the Open Repository Program.

Requests for access to the Open Repository

Requests for NPR materials will be accepted from research organizations and individual investigators in the form of a brief proposal (up to 5 pages) formatted as follows:

  1. Introduction.
  2. Research Hypothesis.
  3. Screening Process, together with description of the characteristics of the screen.
  4. Personnel.
  5. Organizational Research Capabilities.

Requests will normally be reviewed by a committee of the NCI Division of Cancer Treatment and Diagnosis (DCTD) staff appointed by the Director, DCTD. Ad hoc members from outside the Division, Institute, or NIH may be appointed as needed, while ensuring appropriate confidentiality of information provided in the proposal.

The review will consider primarily the scientific merit of the proposal related to the screening target for drug discovery, and the chemical and pharmaceutical expertise for adequate follow-up on the natural products supplied from the NPR.

The Committee to review applications for access to the Natural Products Repository will accept and review proposals on a continuing basis.

Distribution of materials from the Open Repository

On identification of active extracts, investigators will communicate with NPB directly by e-mail of fax, and will be informed whether or not the active materials are available. The test results and requests for additional samples of active extracts are submitted to:

Mrs. Erma Brown
Frederick National Laboratory for Cancer Research (FNLCR)
NPB, DTP, DCTD
P.O. Box B
1050 Boyles Street
Frederick, MD 21701-1201
Phone: 301-624-1285
FAX: 301-631-3026
Email: ebrown@mail.nih.gov

Requests must be copied to:

Dr. Newman newmand@mail.nih.gov

Investigators will have active samples reserved for further investigation on a first-come first-serve basis. Where more than one investigator observes activity for a particular extract, it will be reserved for the first investigator to report activity, and a waiting list of other interested investigators will be established.

Extracts will not be available if they are under active study (on reserve) in either the Open Repository Program (maximum of 6 months exclusivity) or Active Repository Program (up to 15 months exclusivity with the possibility of extension, if necessary).

Once the relevant extract is released by the first investigator, it will be shipped to the next in line on the waiting list.

The maximum period of exclusivity on any extract is 6 months.

Further technical information may be obtained from:

Dr. David Newman
Frederick National Laboratory for Cancer Research (FNLCR)
NPB, DTP, DCTD
P.O. Box B
1050 Boyles Street
Frederick, MD 21701-1201
Phone: 301-624-1285
FAX: 301-631-3026
Email: newmand@mail.nih.gov