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Available Public Data

The DTP Human Tumor Cell Line Screen has checked tens of thousands of compounds for evidence of the ability to inhibit the growth of human tumor cell lines. Available here are screening results and chemical structural data on compounds that are not covered by a confidentiality agreement. We anticipate that this list will be updated at least once a year.

Searchable Results

Screening Results (September 2014 Release)

The compounds submitted to the cancer screen are generally tested at five different concentrations for the ability to inhibit sixty different human tumor cell lines. The dose respose data is used to calculate three concentration parameters.

The Cancer Screening Results (September 2014 Release) can be downloaded in bulk via compressed files. Caution: Each of these files is about 20MB and uncompresses to about 185 MB

Each is a gzip compressed ASCII file containing the results for ~43,000 compounds. The usual .Z (or .gz) file type was changed to .BIN to make sure the browser doesn't try to uncompress on the fly and write the 185 MB to your screen. You should save the file to your disk and uncompress, which will result in an ASCII file with 11 comma delimited fields per record:

Please note the links for more information on the SNB-19, U251, NCI/ADR-RES, and MDA-MB-435 cell lines.

Dose Reponse Set Data

The Dose Reponse Screening Results (September 2012 Release) can be downloaded in bulk via two compressed files.

One Dose Set Data

The One Dose Screening Results (September 2012 Release) can be downloaded in bulk via a compressed file. Caution: This file is about 5MB and uncompresses to about 50MB

The file is a gzip compressed ASCII file containing the results for ~43,000 compounds. The usual .Z (or .gz) file type was changed to .BIN to make sure Netscape doesn't try to uncompress on the fly and write the 50 MB to your screen. You should save the file to your disk and uncompress, which will result in an ASCII file with 11 comma delimited fields per record:

Diversity Set Data

The Diversity Set Results (August 1999 Release) can be accessed as text files. Each file is approximately 5.6Mb.

Chemical Structural Data

Cancer Screen (December 2010 Release)

The 2D structures were retrieved from the DTP's Drug Information System.