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Status Of Compounds

For the sake of historical interest, this volume of "NCI Investigational Drugs; Chemical Informations" includes all those compounds which have been slated for clinical development since at least 1981. By far the majority of the entries in this edition are being developed for IND filing or actually in the clinic. The Table below list those on which the IND has been inactivated and those which are now available commercially.

Chemical Name NSC Number In vitro Cancer Data Structure Pharma. Info Mechanism Status as of April 2012
2-Cl-2'-deoxyadenosine 105014 Yes Yes   Antimetabolite FDA Approved
3-Deazauridine 126849 Yes Yes     NCI IND Closed
4-Nitroestrone 321803 Yes Yes     NCI IND Not Filed
6-Methylmercaptopurine riboside 40774 Yes Yes Yes   NCI IND Closed
9-Aminocamptothecin 603071 Yes Yes Yes Topoisomerase I Inhibitor NCI IND Closed
Acivicin 163501 Yes Yes   RNA/DNA Antimetabolite NCI IND Closed
Acodazole HCl 305884 Yes Yes     NCI IND Closed
ADR-529 (ICRF-187) 169780 Yes Yes     NCI IND Closed
Amascrine 249992 Yes Yes   Topoisomerase II Inhibitor NCI IND Closed
Aminothiadiazole 4728 Yes Yes Yes   NCI IND Closed
Amonafide 308847 Yes Yes   Topoisomerase II Inhibitor NCI IND Closed
Antibiotic FR 901228 630176 Yes Yes Yes HDAC Inhibitor FDA Approved
Aphidicolin Glycinate 303812 Yes Yes   DNA Antimetabolite NCI IND Closed
Azacitidine 102816 Yes Yes Yes Hypomethylation FDA Approved
AZT (For HIV) 602670 Yes Yes   RT Inhibitor FDA Approved
Bizelesin 615291 Yes Yes Yes Alkylating Agent NCI IND Closed
Brefeldin A Analog 656202 Yes Yes   Golgi apparatus effector NCI IND Not Filed
Bromodeoxyuridine 38297 Yes Yes Yes   NCI IND Closed
Bryostatin 339555 Yes Yes Yes   NCI IND Closed
BSO 326231 Yes Yes Yes   NCI IND Closed
CAI 609974 Yes Yes Yes   NCI IND Closed
Caracemide 253272 Yes Yes     NCI IND Closed
Carboplatin 241240 Yes Yes   Alkylating Agent FDA Approved
Chlorosulfaquinoxaline Sulfonamide 339004 Yes Yes Yes   NCI IND Closed
Cisplatin 119875 Yes Yes   Alkylating Agent FDA Approved
Clomesone 338947 Yes Yes   Alkylating Agent NCI IND Closed
Cyclocytidine HCl 145668 Yes Yes   DNA Antimetabolite NCI IND Closed
Cyclodisone 348948 Yes Yes   Alkylating Agent NCI IND Closed
Cyclopentenylcytosine 375575 Yes Yes     NCI IND Closed
Deoxyspergualin 356894 Yes Yes     NCI IND Closed
DHAC 264880 Yes Yes Yes   NCI IND Closed
Diaziquone 182986 Yes Yes     NCI IND Closed
Didemnin B 325319 Yes Yes     NCI IND Closed
Dideoxy-.beta.-fluoroadenosine 613792 Yes Yes Yes RT Inhibitor NCI IND Closed
Dideoxyadenosine (HIV) 98700 Yes Yes   RT Inhibitor NCI IND Closed
Dideoxycytidine 606170 Yes Yes   RT Inhibitor FDA Approved
Dideoxyinosine 612049 Yes Yes   RT Inhibitor FDA Approved
Dihydrotriazine Benzenesulfonyl Fluoride 127755 Yes Yes   Antifolate NCI IND Closed
Dolastatin 10 376128 Yes Yes Yes Antimitotic NCI IND Closed
Ecteinascidin 743 648766 Yes Yes   Topoisomerase II Inhibitor NCI IND Not Filed
Etanidazole 301467 Yes Yes   Radiosensitizer NCI IND Closed
Ethiofos (WR-2721) 296961 Yes Yes   Radioprotector FDA Approved
Fazarabine 281272 Yes Yes Yes   NCI IND Closed
Flavone Acetic Acid 347512 Yes Yes     NCI IND Closed
Flavopiridol 649890 Yes Yes Yes CDK Inhibitor Phase II
Fludarabine Phosphate 312887 Yes Yes   Antimetabolite FDA Approved
Fostriecin 339638 Yes Yes     NCI IND Closed
Gallium Nitrate 15200 Yes Yes Yes   NCI IND Closed
Genistein 36586 Yes Yes   Preventive Agent NCI IND Not Filed
Hepsulfam 329680 Yes Yes   Alkylating Agent NCI IND Closed
HMBA 95580 Yes Yes     NCI IND Closed
Homoharringtonine 141633 Yes Yes Yes   NCI IND Closed
Hydrazine Sulfate 150014 Yes Yes     NCI IND Closed
Iododeoxyuridine 39661 Yes Yes Yes Radiosensitizer NCI IND Closed
Ipomeanol 349438 Yes Yes     NCI IND Closed
KNI-272 651714 Yes Yes Yes HIV Protease Inhibitor NCI IND Closed
Leucovorin Calcium 3590 Yes Yes     FDA Approved
Levamisole 177023 Yes Yes     FDA Approved
Melphalan 8806 Yes Yes   Alkylating Agent FDA Approved
Menogaril 269148 Yes Yes   Topoisomerase II Inhibitor NCI IND Closed
Merbarone 336628 Yes Yes     NCI IND Closed
Methotrexate 740 Yes Yes   Antifolate FDA Approved
Misonidazole 261037 Yes Yes     NCI IND Closed
Mitindomide 284356 Yes Yes     NCI IND Not Filed
Mitoguazone 32946 Yes Yes     NCI IND Closed
Mitoxantrone HCl 301739 Yes Yes   Alkylating Agent FDA Approved
Mitozolomide 353451 Yes Yes   Alkylating Agent NCI IND Not Filed
N-Methylformamide 3051 Yes Yes     NCI IND Closed
O6-Benzylguanine 637037 Yes Yes Yes   NCI IND Open
PALA 224131 Yes Yes Yes RNA/DNA Antimetabolite NCI INC Closed
Pancratistatin 349156 Yes Yes     Not Filed
PCNU 95466 Yes Yes   Alkylating Agent NCI IND Closed
Penclomedine 338720 Yes Yes Yes   NCI IND Closed
Pentamethylmelamine HCl 118742 Yes Yes     NCI IND Closed
Pentamidine Isethionate 620107 Yes Yes     FDA Approved
Pentostatin 218321 Yes Yes   Antimetabolite FDA Approved
Perillyl Alcohol 641066 Yes Yes Yes Differentiation Agent NCI IND Closed
Phyllanthoside 328426 Yes Yes     NCI IND Not Filed
Pibenzimole HCl 322921 Yes Yes     NCI IND Closed
Piroxantrone 349174 Yes Yes Yes   NCI IND Closed
Pyrazine Diazohydroxide 361456 Yes Yes Yes   NCI IND Closed
Pyrazoloacridine 366140 Yes Yes Yes Topoisomerase II Inhibitor NCI IND Closed
Quinocarmycin analog 607097 Yes Yes Yes   NCI IND Closed
Rebeccamycin Analog 655649 Yes Yes Yes   NCI IND Closed
Rhizoxin 332598 Yes Yes Yes Antimototic NCI IND Closed
Semustine (Methyl CCNU) 95441 Yes Yes   Alkylating Agent NCI IND Closed
Suramin Sodium 34936 Yes Yes     NCI IND Closed
Taxol 125973 Yes Yes   Antimitotic FDA Approved
Temozolomide 362856 Yes Yes     FDA Approved
Terephthalamidine 57155 Yes Yes     NCI IND Closed
Teroxirone 296934 Yes Yes   Alkylating Agent NCI IND Closed
Thioguanine 752 Yes Yes Yes DNA Antimetabolite FDA Approved
Thymidine 21548 Yes Yes Yes   NCI IND Closed
Tiazofurin 286193 Yes Yes Yes   NCI IND Closed
TMCA 36354 Yes Yes Yes   NCI IND Closed
Topotecan 609699 Yes Yes   Topoisomerase I Inhibitor FDA Approved
Tributyrin 661583 Yes Yes Yes Differentiation Agent NCI IND Closed
Triciribine Phosphate 280594 Yes Yes     NCI IND Closed
Trimetrexate 249008 Yes Yes   Antifolate FDA Approved
UCN-01 638850 Yes Yes Yes PKC Inhibitor NCI IND Open
Uridine 20256 Yes Yes     NCI IND Closed