Status Of Compounds
For the sake of historical interest, this volume of "NCI Investigational Drugs; Chemical Informations" includes all those compounds which have been slated for clinical development since at least 1981. By far the majority of the entries in this edition are being developed for IND filing or actually in the clinic. The Table below list those on which the IND has been inactivated and those which are now available commercially.
| Chemical Name | NSC Number | In vitro Cancer Data | Structure | Pharma. Info | Mechanism | Status |
|---|---|---|---|---|---|---|
| 2-Cl-2'-deoxyadenosine | 105014 | Yes | Yes | Antimetabolite | FDA Approved | |
| 3-Deazauridine | 126849 | Yes | Yes | NCI IND Closed | ||
| 4-Nitroestrone | 321803 | Yes | Yes | NCI IND Not Filed | ||
| 6-Methylmercaptopurine riboside | 40774 | Yes | Yes | Yes | NCI IND Closed | |
| 9-Aminocamptothecin | 603071 | Yes | Yes | Yes | Topoisomerase I Inhibitor | Phase II |
| Acivicin | 163501 | Yes | Yes | RNA/DNA Antimetabolite | NCI IND Closed | |
| Acodazole HCl | 305884 | Yes | Yes | NCI IND Closed | ||
| ADR-529 (ICRF-187) | 169780 | Yes | Yes | NCI IND Open | ||
| Amascrine | 249992 | Yes | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Closed |
| Aminothiadiazole | 4728 | Yes | Yes | Yes | NCI IND Closed | |
| Amonafide | 308847 | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Closed | |
| Antibiotic FR 901228 | 630176 | Yes | Yes | Yes | Phase I | |
| Aphidicolin Glycinate | 303812 | Yes | Yes | DNA Antimetabolite | NCI IND Not Filed | |
| Azacitidine | 102816 | Yes | Yes | Yes | Phase II/III | |
| AZT (For HIV) | 602670 | Yes | Yes | RT Inhibitor | FDA Approved | |
| Bizelesin | 615291 | Yes | Yes | Yes | Alkylating Agent | NCI IND Open |
| Brefeldin A Analog | 656202 | Yes | Yes | Golgi apparatus effector | NCI IND Not Filed | |
| Bromodeoxyuridine | 38297 | Yes | Yes | Yes | NCI IND Open | |
| Bryostatin | 339555 | Yes | Yes | Yes | Phase I/II | |
| BSO | 326231 | Yes | Yes | Yes | NCI IND Open | |
| CAI | 609974 | Yes | Yes | Yes | Phase I | |
| Caracemide | 253272 | Yes | Yes | NCI IND Closed | ||
| Carboplatin | 241240 | Yes | Yes | Alkylating Agent | FDA Approved | |
| Chlorosulfaquinoxaline Sulfonamide | 339004 | Yes | Yes | Yes | NCI IND Open | |
| Cisplatin | 119875 | Yes | Yes | Alkylating Agent | FDA Approved | |
| Clomesone | 338947 | Yes | Yes | Alkylating Agent | NCI IND Not Filed | |
| Cyclocytidine HCl | 145668 | Yes | Yes | DNA Antimetabolite | NCI IND Closed | |
| Cyclodisone | 348948 | Yes | Yes | Alkylating Agent | NCI IND Not Filed | |
| Cyclopentenylcytosine | 375575 | Yes | Yes | NCI IND Closed | ||
| Deoxyspergualin | 356894 | Yes | Yes | NCI IND Closed | ||
| DHAC | 264880 | Yes | Yes | Yes | NCI IND Closed | |
| Diaziquone | 182986 | Yes | Yes | NCI IND Closed | ||
| Didemnin B | 325319 | Yes | Yes | NCI IND Closed | ||
| Dideoxy-.beta.-fluoroadenosine | 613792 | Yes | Yes | Yes | RT Inhibitor | NCI IND To Be Closed |
| Dideoxyadenosine (HIV) | 98700 | Yes | Yes | RT Inhibitor | NCI IND Closed | |
| Dideoxycytidine | 606170 | Yes | Yes | RT Inhibitor | NCI IND Closed | |
| Dideoxyinosine | 612049 | Yes | Yes | RT Inhibitor | NCI IND Closed | |
| Dihydrotriazine Benzenesulfonyl Fluoride | 127755 | Yes | Yes | Antifolate | NCI IND Closed | |
| Dolastatin 10 | 376128 | Yes | Yes | Yes | Antimitotic | Phase I |
| Ecteinascidin 743 | 648766 | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Not Filed | |
| Etanidazole | 301467 | Yes | Yes | Radiosensitizer | NCI IND Closed | |
| Ethiofos (WR-2721) | 296961 | Yes | Yes | Radioprotector | NCI IND Closed | |
| Fazarabine | 281272 | Yes | Yes | Yes | NCI IND Closed | |
| Flavone Acetic Acid | 347512 | Yes | Yes | NCI IND Closed | ||
| Flavopiridol | 649890 | Yes | Yes | Yes | CDK Inhibitor | Phase II |
| Fludarabine Phosphate | 312887 | Yes | Yes | Antimetabolite | FDA Approved | |
| Fostriecin | 339638 | Yes | Yes | NCI IND Closed | ||
| Gallium Nitrate | 15200 | Yes | Yes | Yes | NCI IND Closed | |
| Genistein | 36586 | Yes | Yes | Preventive Agent | NCI IND Not Filed | |
| Hepsulfam | 329680 | Yes | Yes | Alkylating Agent | NCI IND Closed | |
| HMBA | 95580 | Yes | Yes | NCI IND Closed | ||
| Homoharringtonine | 141633 | Yes | Yes | Yes | Phase II/III | |
| Hydrazine Sulfate | 150014 | Yes | Yes | NCI IND Closed | ||
| Iododeoxyuridine | 39661 | Yes | Yes | Yes | Radiosensitizer | NCI IND Closed |
| Ipomeanol | 349438 | Yes | Yes | NCI IND Closed | ||
| KNI-272 | 651714 | Yes | Yes | Yes | HIV Protease Inhibitor | NCI IND Closed |
| Leucovorin Calcium | 3590 | Yes | Yes | NCI IND Closed | ||
| Levamisole | 177023 | Yes | Yes | FDA Approved | ||
| Melphalan | 8806 | Yes | Yes | Alkylating Agent | FDA Approved | |
| Menogaril | 269148 | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Closed | |
| Merbarone | 336628 | Yes | Yes | NCI IND Closed | ||
| Methotrexate | 740 | Yes | Yes | Antifolate | FDA Approved | |
| Misonidazole | 261037 | Yes | Yes | NCI IND Closed | ||
| Mitindomide | 284356 | Yes | Yes | NCI IND Not Filed | ||
| Mitoguazone | 32946 | Yes | Yes | NCI IND Closed | ||
| Mitoxantrone HCl | 301739 | Yes | Yes | Alkylating Agent | FDA Approved | |
| Mitozolomide | 353451 | Yes | Yes | Alkylating Agent | NCI IND Not Filed | |
| N-Methylformamide | 3051 | Yes | Yes | NCI IND Closed | ||
| O6-Benzylguanine | 637037 | Yes | Yes | Yes | NCI IND Open | |
| PALA | 224131 | Yes | Yes | Yes | RNA/DNA Antimetabolite | NCI INC Closed |
| Pancratistatin | 349156 | Yes | Yes | |||
| PCNU | 95466 | Yes | Yes | Alkylating Agent | NCI IND Closed | |
| Penclomedine | 338720 | Yes | Yes | Yes | NCI IND Open | |
| Pentamethylmelamine HCl | 118742 | Yes | Yes | NCI IND Closed | ||
| Pentamidine Isethionate | 620107 | Yes | Yes | |||
| Pentostatin | 218321 | Yes | Yes | Antimetabolite | FDA Approved | |
| Perillyl Alcohol | 641066 | Yes | Yes | Yes | Differentiation Agent | Phase II |
| Phyllanthoside | 328426 | Yes | Yes | NCI IND Not Filed | ||
| Pibenzimole HCl | 322921 | Yes | Yes | NCI IND Closed | ||
| Piroxantrone | 349174 | Yes | Yes | Yes | NCI IND Closed | |
| Pyrazine Diazohydroxide | 361456 | Yes | Yes | Yes | NCI IND Closed | |
| Pyrazoloacridine | 366140 | Yes | Yes | Yes | Topoisomerase II Inhibitor | Phase II |
| Quinocarmycin analog | 607097 | Yes | Yes | Yes | NCI IND Closed | |
| Rebeccamycin Analog | 655649 | Yes | Yes | Yes | Phase II | |
| Rhizoxin | 332598 | Yes | Yes | Yes | Antimototic | NCI IND Closed |
| Semustine (Methyl CCNU) | 95441 | Yes | Yes | Alkylating Agent | NCI IND Closed | |
| Suramin Sodium | 34936 | Yes | Yes | NCI IND Open | ||
| Taxol | 125973 | Yes | Yes | Antimitotic | FDA Approved | |
| Temozolomide | 362856 | Yes | Yes | FDA Approved | ||
| Terephthalamidine | 57155 | Yes | Yes | NCI IND Closed | ||
| Teroxirone | 296934 | Yes | Yes | Alkylating Agent | NCI IND Closed | |
| Thioguanine | 752 | Yes | Yes | Yes | DNA Antimetabolite | FDA Approved |
| Thymidine | 21548 | Yes | Yes | Yes | Phase II | |
| Tiazofurin | 286193 | Yes | Yes | Yes | NCI IND Closed | |
| TMCA | 36354 | Yes | Yes | Yes | NCI IND Closed | |
| Topotecan | 609699 | Yes | Yes | Topoisomerase I Inhibitor | NCI IND Open | |
| Tributyrin | 661583 | Yes | Yes | Yes | Differentiation Agent | Phase I |
| Triciribine Phosphate | 280594 | Yes | Yes | NCI IND Closed | ||
| Trimetrexate | 249008 | Yes | Yes | Antifolate | NCI IND Closed | |
| UCN-01 | 638850 | Yes | Yes | Yes | PKC Inhibitor | NCI IND Open |
| Uridine | 20256 | Yes | Yes | NCI IND Closed |