Status Of Compounds

For the sake of historical interest, this volume of "NCI Investigational Drugs; Chemical Informations" includes all those compounds which have been slated for clinical development since at least 1981. By far the majority of the entries in this edition are being developed for IND filing or actually in the clinic. The Table below list those on which the IND has been inactivated and those which are now available commercially.

Chemical Name | NSC Number | In vitro Cancer Data | Structure | Pharma. Info | Mechanism | Status as of April 2012 |
---|---|---|---|---|---|---|

2-Cl-2'-deoxyadenosine | 105014 | Yes | Yes | Antimetabolite | FDA Approved | |

3-Deazauridine | 126849 | Yes | Yes | NCI IND Closed | ||

4-Nitroestrone | 321803 | Yes | Yes | NCI IND Not Filed | ||

6-Methylmercaptopurine riboside | 40774 | Yes | Yes | Yes | NCI IND Closed | |

9-Aminocamptothecin | 603071 | Yes | Yes | Yes | Topoisomerase I Inhibitor | NCI IND Closed |

Acivicin | 163501 | Yes | Yes | RNA/DNA Antimetabolite | NCI IND Closed | |

Acodazole HCl | 305884 | Yes | Yes | NCI IND Closed | ||

ADR-529 (ICRF-187) | 169780 | Yes | Yes | NCI IND Closed | ||

Amascrine | 249992 | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Closed | |

Aminothiadiazole | 4728 | Yes | Yes | Yes | NCI IND Closed | |

Amonafide | 308847 | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Closed | |

Antibiotic FR 901228 | 630176 | Yes | Yes | Yes | HDAC Inhibitor | FDA Approved |

Aphidicolin Glycinate | 303812 | Yes | Yes | DNA Antimetabolite | NCI IND Closed | |

Azacitidine | 102816 | Yes | Yes | Yes | Hypomethylation | FDA Approved |

AZT (For HIV) | 602670 | Yes | Yes | RT Inhibitor | FDA Approved | |

Bizelesin | 615291 | Yes | Yes | Yes | Alkylating Agent | NCI IND Closed |

Brefeldin A Analog | 656202 | Yes | Yes | Golgi apparatus effector | NCI IND Not Filed | |

Bromodeoxyuridine | 38297 | Yes | Yes | Yes | NCI IND Closed | |

Bryostatin | 339555 | Yes | Yes | Yes | NCI IND Closed | |

BSO | 326231 | Yes | Yes | Yes | NCI IND Closed | |

CAI | 609974 | Yes | Yes | Yes | NCI IND Closed | |

Caracemide | 253272 | Yes | Yes | NCI IND Closed | ||

Carboplatin | 241240 | Yes | Yes | Alkylating Agent | FDA Approved | |

Chlorosulfaquinoxaline Sulfonamide | 339004 | Yes | Yes | Yes | NCI IND Closed | |

Cisplatin | 119875 | Yes | Yes | Alkylating Agent | FDA Approved | |

Clomesone | 338947 | Yes | Yes | Alkylating Agent | NCI IND Closed | |

Cyclocytidine HCl | 145668 | Yes | Yes | DNA Antimetabolite | NCI IND Closed | |

Cyclodisone | 348948 | Yes | Yes | Alkylating Agent | NCI IND Closed | |

Cyclopentenylcytosine | 375575 | Yes | Yes | NCI IND Closed | ||

Deoxyspergualin | 356894 | Yes | Yes | NCI IND Closed | ||

DHAC | 264880 | Yes | Yes | Yes | NCI IND Closed | |

Diaziquone | 182986 | Yes | Yes | NCI IND Closed | ||

Didemnin B | 325319 | Yes | Yes | NCI IND Closed | ||

Dideoxy-.beta.-fluoroadenosine | 613792 | Yes | Yes | Yes | RT Inhibitor | NCI IND Closed |

Dideoxyadenosine (HIV) | 98700 | Yes | Yes | RT Inhibitor | NCI IND Closed | |

Dideoxycytidine | 606170 | Yes | Yes | RT Inhibitor | FDA Approved | |

Dideoxyinosine | 612049 | Yes | Yes | RT Inhibitor | FDA Approved | |

Dihydrotriazine Benzenesulfonyl Fluoride | 127755 | Yes | Yes | Antifolate | NCI IND Closed | |

Dolastatin 10 | 376128 | Yes | Yes | Yes | Antimitotic | NCI IND Closed |

Ecteinascidin 743 | 648766 | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Not Filed | |

Etanidazole | 301467 | Yes | Yes | Radiosensitizer | NCI IND Closed | |

Ethiofos (WR-2721) | 296961 | Yes | Yes | Radioprotector | FDA Approved | |

Fazarabine | 281272 | Yes | Yes | Yes | NCI IND Closed | |

Flavone Acetic Acid | 347512 | Yes | Yes | NCI IND Closed | ||

Flavopiridol | 649890 | Yes | Yes | Yes | CDK Inhibitor | Phase II |

Fludarabine Phosphate | 312887 | Yes | Yes | Antimetabolite | FDA Approved | |

Fostriecin | 339638 | Yes | Yes | NCI IND Closed | ||

Gallium Nitrate | 15200 | Yes | Yes | Yes | NCI IND Closed | |

Genistein | 36586 | Yes | Yes | Preventive Agent | NCI IND Not Filed | |

Hepsulfam | 329680 | Yes | Yes | Alkylating Agent | NCI IND Closed | |

HMBA | 95580 | Yes | Yes | NCI IND Closed | ||

Homoharringtonine | 141633 | Yes | Yes | Yes | NCI IND Closed | |

Hydrazine Sulfate | 150014 | Yes | Yes | NCI IND Closed | ||

Iododeoxyuridine | 39661 | Yes | Yes | Yes | Radiosensitizer | NCI IND Closed |

Ipomeanol | 349438 | Yes | Yes | NCI IND Closed | ||

KNI-272 | 651714 | Yes | Yes | Yes | HIV Protease Inhibitor | NCI IND Closed |

Leucovorin Calcium | 3590 | Yes | Yes | FDA Approved | ||

Levamisole | 177023 | Yes | Yes | FDA Approved | ||

Melphalan | 8806 | Yes | Yes | Alkylating Agent | FDA Approved | |

Menogaril | 269148 | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Closed | |

Merbarone | 336628 | Yes | Yes | NCI IND Closed | ||

Methotrexate | 740 | Yes | Yes | Antifolate | FDA Approved | |

Misonidazole | 261037 | Yes | Yes | NCI IND Closed | ||

Mitindomide | 284356 | Yes | Yes | NCI IND Not Filed | ||

Mitoguazone | 32946 | Yes | Yes | NCI IND Closed | ||

Mitoxantrone HCl | 301739 | Yes | Yes | Alkylating Agent | FDA Approved | |

Mitozolomide | 353451 | Yes | Yes | Alkylating Agent | NCI IND Not Filed | |

N-Methylformamide | 3051 | Yes | Yes | NCI IND Closed | ||

O6-Benzylguanine | 637037 | Yes | Yes | Yes | NCI IND Open | |

PALA | 224131 | Yes | Yes | Yes | RNA/DNA Antimetabolite | NCI INC Closed |

Pancratistatin | 349156 | Yes | Yes | Not Filed | ||

PCNU | 95466 | Yes | Yes | Alkylating Agent | NCI IND Closed | |

Penclomedine | 338720 | Yes | Yes | Yes | NCI IND Closed | |

Pentamethylmelamine HCl | 118742 | Yes | Yes | NCI IND Closed | ||

Pentamidine Isethionate | 620107 | Yes | Yes | FDA Approved | ||

Pentostatin | 218321 | Yes | Yes | Antimetabolite | FDA Approved | |

Perillyl Alcohol | 641066 | Yes | Yes | Yes | Differentiation Agent | NCI IND Closed |

Phyllanthoside | 328426 | Yes | Yes | NCI IND Not Filed | ||

Pibenzimole HCl | 322921 | Yes | Yes | NCI IND Closed | ||

Piroxantrone | 349174 | Yes | Yes | Yes | NCI IND Closed | |

Pyrazine Diazohydroxide | 361456 | Yes | Yes | Yes | NCI IND Closed | |

Pyrazoloacridine | 366140 | Yes | Yes | Yes | Topoisomerase II Inhibitor | NCI IND Closed |

Quinocarmycin analog | 607097 | Yes | Yes | Yes | NCI IND Closed | |

Rebeccamycin Analog | 655649 | Yes | Yes | Yes | NCI IND Closed | |

Rhizoxin | 332598 | Yes | Yes | Yes | Antimototic | NCI IND Closed |

Semustine (Methyl CCNU) | 95441 | Yes | Yes | Alkylating Agent | NCI IND Closed | |

Suramin Sodium | 34936 | Yes | Yes | NCI IND Closed | ||

Taxol | 125973 | Yes | Yes | Antimitotic | FDA Approved | |

Temozolomide | 362856 | Yes | Yes | FDA Approved | ||

Terephthalamidine | 57155 | Yes | Yes | NCI IND Closed | ||

Teroxirone | 296934 | Yes | Yes | Alkylating Agent | NCI IND Closed | |

Thioguanine | 752 | Yes | Yes | Yes | DNA Antimetabolite | FDA Approved |

Thymidine | 21548 | Yes | Yes | Yes | NCI IND Closed | |

Tiazofurin | 286193 | Yes | Yes | Yes | NCI IND Closed | |

TMCA | 36354 | Yes | Yes | Yes | NCI IND Closed | |

Topotecan | 609699 | Yes | Yes | Topoisomerase I Inhibitor | FDA Approved | |

Tributyrin | 661583 | Yes | Yes | Yes | Differentiation Agent | NCI IND Closed |

Triciribine Phosphate | 280594 | Yes | Yes | NCI IND Closed | ||

Trimetrexate | 249008 | Yes | Yes | Antifolate | FDA Approved | |

UCN-01 | 638850 | Yes | Yes | Yes | PKC Inhibitor | NCI IND Open |

Uridine | 20256 | Yes | Yes | NCI IND Closed |