NSC 141633

Chemical Data

How Supplied

For Injection, 5 mg, vial: The product is supplied as a lyophilized powder in 10 mL amber vials with mannitol, USP, 50 mg and hydrochloric acid to adjust pH.

Solution Preparation

Vial, 5 mg: When constituted with 4.9 mL of 0.9% Sodium Chloride Injection, USP, each milliliter contains 1 mg of homoharringtonine with 10 mg of mannitol, USP, and hydrochloric acid to adjust the pH to 3.5 to 5.5.

Storage

Store the intact vials in the refrigerator (4 to 8 °).

Stability

Intact vials are stable for 5 years at room temperature (22-25 °).

Constitution as recommended results in a solution which is chemically and physically stable for a minimum of 96 hours at room temperature under normal fluorescent lighting.

Further dilution of the constituted solution to concentrations of 0.05 mg/mL and 0.01 mg/mL in 0.9% Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP, also results in solutions which are chemically and physically stable for at least 96 hours at room temperature under normal fluorescent lighting.

CAUTION: The single-use lyophilized dosage form contains no antibacterial preservatives. Therefore, it is advised that the constituted product be discarded within 8 hours of initial entry.

Route of Administration

Intravenous