NSC 40774
Chemical Data
How Supplied
Sterile, 50 mg, vial: supplied as a white lyophilized powder with 100 mg of mannitol, USP, in a 20 mL flint vial.
Solution Preparation
50 mg/vial: When constituted with 10 mL of 0.9% SOdium Chloride Injection, USP, each milliliter of the resultant solution contains 5 mg of 6-methylmercaptopurine riboside and 10 mg of mannitol, USP, at pH 5.0 to 7.5.
CAUTION: Use only if a vacuum is present.
Storage
Store the intact vials under refrigeration (2-8 °).
Stability
Intact vials are stable for at least four years when stored at room temperature (22-25 °).
Constituted solutions of 6-methylmercaptopurine riboside exhibit no decomposition for at least 24 hours at room temperature.
NOTE: A precipitate may be present after constitution. However, the precipitate is 6-MMPR and can be easily redissolved by warming under hot tap water.
Further dilution to a concentration of 0.1 mg/mL in 5 % Dextrose in 0.9% Sodium Chloride Injection, USP, also results in solutions exhibiting no decomposition for at least 24 hours at room temperature.
CAUTION: The single-use lyophilized dosage form contains no antibacterial preservatives. Therefore, it is advised that the constituted product be discarded within 8 hours of initial entry.
Route of Administration
Intravenous