NSC 648766
Structure
If clicking on the 2D structure does not bring up the 3D structure, you need to configure your browser to handle Chemical MIME types
Names
- Ecteinascidin 743
Chemical Data
CAS Registry Number: 114899-77-3
Molecular Formula: C39H43N3O11S
Molecular Weight: 762
Approximate Solubility
| Solvent | Solubility ( mg/mL ) |
|---|---|
| pH 4.0 0.05 M Phosphate buffer | 0.44 |
| Ethanol | > 1 |
Stability
- Bulk: Ecteinascidin 743 is stored at -20 ° C in the absence of formal bulk stability data
- Solution: Solutions of NSC 648766 (0.1 mg/mL) in pH 4.0 buffer are stable for approximately 2 days at room temperature and for at least 30 days at 4 ° C. Solvents which contained ethanol showed significant loss of drug by one day at room temperature and one week at 4 ° C
Ultraviolet Absorption
in MeOH| lambda max | epsilon |
|---|---|
| 287 | 6,200 |
| 240 | 15,000 |
High Performance Liquid Chromatography
- Column: Phenomenex Selectosil C-18 5 µ 250 mm × 4.6 mm
- Mobile Phase: 0.05 M pH 3 Tris buffer:acetonitrile 75:45
- Flow Rate: 1 mL/min
- Detection: UV at 254 nm
- Sample Preparation: 0.8 mg of the sample is dissolved in 1 mL ethanol
- Retention Volume: 8.1 mL
Optical Rotation
(c = 0.1 MeOH) [alpha]20D = +114 °